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Anti-GCR Polyclonal Antibody
產(chǎn)品簡介：

Anti-GCR Polyclonal Antibody
應(yīng)用 WB
稀釋比例WB 1:3000.
交叉反應(yīng)Human

產(chǎn)品型號：K101529P

更新時間：2022-08-15

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產(chǎn)品介紹

Anti-GCR Polyclonal Antibody

英文名稱Anti-GCR Polyclonal Antibody
宿主Rabbit
別名GCCR;GCR;GCRST;GR;GRL
應(yīng)用WB
稀釋比例WB 1:3000.
交叉反應(yīng)Human
蛋白分子量86kDa
Gene ID2908
保存Store at -20°C. Avoid freeze / thaw cycles.
儲存液Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
純化方法Affinity purification
亞型IgG
免疫原A synthetic peptide of human GCR
性狀液體
Public Immunogen Range

A synthetic peptide of human GCR

Subcellular LocationsCytoplasm Mitochondrion Nucleus Nucleus
Swiss ProtP04150
克隆類型Polyclonal Antibody
背景資料

Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling. Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth.

 

Anti-GCR Polyclonal Antibody

 

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